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What is the difference?

Combined pill vs Progestogen-only pill

Both are daily contraceptive tablets, so they are often just called "the pill". The difference is in the hormones: the combined pill contains an estrogen and a progestogen, while the progestogen-only pill contains a progestogen alone.

General information, not medical advice. For advice about your own situation, talk to a clinician, pharmacist or sexual health clinic.

Combined pill

The combined pill is a daily tablet containing an estrogen and a progestogen that prevents pregnancy mainly by stopping ovulation.

Full entry

Progestogen-only pill

The progestogen-only pill is a daily contraceptive tablet containing only a progestogen hormone, taken every day without a break.

Full entry

Side by side

Combined pillProgestogen-only pill
HormonesCombined pillAn estrogen plus a progestogen.Progestogen-only pillA progestogen only, no estrogen.
Main way it worksCombined pillMainly stops ovulation.Progestogen-only pillThickens cervical mucus and thins the uterine lining; some types also stop ovulation.
Taking itCombined pillTraditionally 21 days then a seven-day break, though shorter or no breaks are now common.Progestogen-only pillEvery day without a break.
Late pill windowCombined pillHas its own missed-pill rules.Progestogen-only pillSome types must be taken within three hours each day, others allow up to twelve.
Who may use itCombined pillNot suitable for some people, e.g. with some migraines, a history of clots, or who smoke and are over 35.Progestogen-only pillOften suitable for people who cannot take estrogen, including when breastfeeding.
BleedingCombined pillPeriods often become lighter and more regular.Progestogen-only pillIrregular bleeding is common, especially in the first months.

In short

The combined pill has two hormones and usually allows planned breaks; the progestogen-only pill has one hormone, is taken without a break and suits many people who cannot take estrogen.

What they have in common

Both are taken daily, are more than 99% effective with perfect use and around 91% with typical use, and neither protects against STIs.

Sources

  1. NHSCombined pill
  2. NHSThe progestogen-only pill

More comparisons

Last reviewed 10 October 2026. Spotted a mistake?