Heart Lexicon

What is the difference?

Hepatitis B vs Hepatitis C

Hepatitis B and hepatitis C are both viruses that infect the liver and can cause long-term damage, which is why they are often mentioned together. They differ in how they usually spread, whether a vaccine exists and whether treatment can cure them.

General information, not medical advice. For advice about your own situation, talk to a clinician, pharmacist or sexual health clinic.

Hepatitis B

Hepatitis B is a viral infection of the liver spread through blood and sexual fluids; it can be prevented with a vaccine.

Full entry

Hepatitis C

Hepatitis C is a viral liver infection spread mainly through blood; sexual transmission is less common but possible, and modern tablets cure most cases.

Full entry

Side by side

Hepatitis BHepatitis C
Main routesHepatitis BBlood and body fluids, including sex without a condom, and from parent to baby at birth.Hepatitis CMainly blood, for example shared injecting equipment or unsafe medical procedures; sexual transmission is less common.
VaccineHepatitis BYes, a safe and highly effective vaccine, often given in infancy.Hepatitis CNo vaccine is available.
Chance of long-term infectionHepatitis BLess than 5% in adults, but about 95% when caught in infancy or early childhood.Hepatitis CAbout 70% of people develop long-term infection without treatment.
TreatmentHepatitis BAntiviral medicine controls it but rarely clears it, and is often taken for life.Hepatitis CAntiviral tablets taken for 8 to 12 weeks cure more than 95% of people.
TestingHepatitis BA blood test, which can also show immunity from vaccination.Hepatitis CAn antibody blood test, with a follow-up test to confirm a current infection.

In short

Hepatitis B can be prevented with a vaccine but is usually controlled rather than cured; hepatitis C has no vaccine but can usually be cured.

What they have in common

Both can go unnoticed for years, both can lead to liver scarring and liver cancer if untreated, and both are diagnosed with a blood test.

Sources

  1. WHOHepatitis B fact sheet
  2. WHOHepatitis C fact sheet
  3. NHSHepatitis C

More comparisons

Last reviewed 16 October 2026. Spotted a mistake?